Quantitative Analysis of ADC Components – Ligand Binding Assay (LBA) and LC-MS/MS
There are both large and small ADC molecules.
A variety of biological analysis methods and platforms are needed to analyze the diversity of ADCs.
Conventional LC-MS/MS small-molecule assays are often used to analyze uncoupled payloads and DAR distributions over time, while ligand binding assays (LBA) and LC-MS/MS can also be used to analyze total antibodies (TAb) and total ADCs.
The choice of analysis platform depends on the availability of key reagents, the required analytical sensitivity and the different problems that need to be addressed at various stages of drug development.
In this article, the classical LBA and LC-MS/MS methods for quantitative analysis of ADC components are briefly introduced.
|Monday||Open (24 Hours)|
|Tuesday||Open Today (24 Hours)|
|Wednesday||Open (24 Hours)|
|Thursday||Open (24 Hours)|
|Friday||Open (24 Hours)|
|Saturday||Open (24 Hours)|
|Sunday||Open (24 Hours)|