Overview
2-Chlorotrityl chloride resin is a highly adaptable resin used for the solid-phase immobilization of various chemical functionalities, including:
Carboxylic acids
Alcohols & Phenols
Amines, Imidazoles, and Hydroxylamines
Cleavage Methods
The functional groups immobilized on 2-Chlorotrityl chloride resin can be efficiently released using:
1–50% TFA in DCM (with 5% TIS for enhanced stability)
AcOH/TFE/DCM solution (for selective cleavage of carboxylic acids)
0.5% TFA in DCM or HFIP in DCM
Applications
Peptide Synthesis — Ideal for solid-phase peptide assembly.
Organic Chemistry — Widely used in the synthesis of protein mimics and complex molecules.
Pharmaceutical Research — Supports the development of bioactive compounds.
Key Benefits
Highly Versatile — Supports a variety of organic functional groups.
Efficient Cleavage — Enables clean and controlled detachment of bound molecules.
Optimized for Peptide Synthesis — Used in Native Chemical Ligation (NCL) for protein mimic assembly.
Scientific References
Backed by extensive research, with applications documented in multiple peer-reviewed journals including:
- Tetrahedron Letters
- Bioorganic & Medicinal Chemistry
- International Journal of Peptide Protein Research
Enhance your solid-phase synthesis with 2-Chlorotrityl chloride resin!
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